Mef2C is a muscle regulatory transcription factor that has been implicated in the regulation of Glut4 in muscle. It has also been implicated as an important transcription factor in muscle fiber-type switching, involved in the specification of type 1 fibers. This is crucial in diabetes because type 1 fibers have a much greater insulin sensitivity than type 1 fibers. In addition, recent data has shown that the key transcritional coactivator PGC1alpha can stimulate a complete program of trans-differentiation of muscle fibers from type 2b to type 2a and type1. Analysis of relevant gene promoters has indicated that MEF2C is an important docking site for PGC-1alpha to execute this program.

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