Diabetes Genome Anatomy Project |
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Resources > Candidate Genes
Candidate Genes
Candidate genes are selected on the basis of the expression profiling results of DGAP. Genes emerging as possible candidates are classified according to the expression pattern (insulin-regulated, insulin-resistance regulated, diabetes-regulated, adipose regulated, and TZD regulated), experimental system (humans, animal models, cell lines), confirmation by RT-PCR or functional data. Genes appearing in multiple expression categories and/or experimental system are selected for genetic analysis, with higher priority given to genes with confirmed expression changes that have not been previously investigated for association with insulin-resistance or type 2 diabetes.
Genetic variability at each candidate locus is charcaterized through two complementary approaches, namely:
i. Validation of SNPs from public databases;
ii. Resequencing of the exons and 5' flanking region.
Polymorphisms from these two sources are used to characterize the haplotype structure of each locus in the HAPMAP panel and identify haplotype-tagging SNPs for association studies.
| NR4A1 | Nuclear receptor subfamily 4, group a, member 1 |
| SIRT2 | Sirtuin 2 |
| MYO1C | Myosin 1C |
| FASN | Fatty acid synthase |
| GK | Glycerol kinase |
| MEF2C | Myocyte enhancer factor 2C |
| SREBF1 | Sterol regulatory element binding transcription factor 1 |
| PERC | PGC-1-related estrogen receptor alpha coactivator |
| PC | Pyruvate carboxylase precursor |
Output produced by Innate Immunity PGA and CHIP bioinformatics tools.
© 2004, DGAP