Diabetes Genome Anatomy Project

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Resources

Data Access

• Public Microarray Data in RAD at UPENN
• Public Microarray Data in ChipperDB
• Private Microarray Data in ChipperDB
• Third Party Data
• GenMAPPs
• Protocols
• Candidate Genes
• Protein Identifications

Publications

• Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes 2005 May;54(5):1314-23 [ Pubmed ]
• Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003 299(5606):572-4 [ Pubmed ]
• Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002 3(1):25-38 [ Pubmed ]
• Bluher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem 2004 279(30):31891-901 [ Pubmed ]
• Bluher M, Wilson-Fritch L, Leszyk J, Laustsen PG, Corvera S, Kahn CR. Role of insulin action and cell size on protein expression patterns in adipocytes. J Biol Chem 2004 279(30):31902-9 [ Pubmed ]
• Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005 Aug 12;122(3):337-49 [ Pubmed ]
• Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME.. ß-Cell Secretory Dysfunction in the Pathogenesis of Low Birth Weight–Associated Diabetes: A Murine Model. Diabetes 2005, 54: 702-711 [ Pubmed ]
• Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jager S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1a Null Mice. Cell 2004 Oct 1; 119(1):121-135 [ Pubmed ]
• Mary Elizabeth Patti, Atul J. Butte, Sarah Crunkhorn, Kenneth Cusi, Rachele Berria, Sangeeta Kashyap, Yoshinori Miyazaki, Isaac Kohane, Maura Costello, Robert Saccone, Edwin J. Landaker, Allison B. Goldfine, Edward Mun, Ralph DeFronzo, Jean Finlayson, C. Ronald Kahn, and Lawrence J. Mandarino. Coordinated Reduction of Genes of Oxidative Metabolism in Humans with Insulin Resistance and Diabetes: Potential Role of PGC1 and NRF-1. PNAS 2003 100(14):8466-71 [ Pubmed ]
• Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest 2003 112(4):608-18 [ Pubmed ]
• Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol 2005 [ Pubmed ]
• Vamsi K. Mootha, Cecilia M. Lindgren, Karl-Fredrik Eriksson, Aravind Subramanian, Smita Sihag, Joseph Lehar, Pere Puigserver, Emma Carlsson, Martin Ridderstrale, Esa Laurila, Nicholas Houstis, Mark J. Daly, Nick Patterson, Jill P. Mesirov, Todd R. Golub, Pablo Tamayo, Bruce Spiegelman, Eric S. Lander, Joel N. Hirschhorn, David Altshuler, and Leif C. Groop. PGC-1a Responsive Genes Involved in Oxidative Phosphorylationare Coordinately Downregulated in Human Diabetes. Nature Genetics 2003 Jul;34(3):267-73. [ Pubmed ]
• Yechoor VK, Patti ME, Saccone R, Kahn CR.. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice.. PNAS 2002 99(16):10587-92 [ Pubmed ]
• Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, Kahn CR. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. PNAS 2004 101(47):16525-30 [ Pubmed ]

Tools

• Affymetrix Affymetrix offers an integrated products and services, including its integrated GeneChip platform, understanding the relationship between genes and human health
• AliBaba2.1 Prediction of transcription factor binding sites by constructing matrices on the fly from TRANSFAC 4.0 sites
• Gene Regulation Resource for tools and database
• GenMAPP Color code genes in known pathways and functional groups based on the results of a microarray expression experiment
• MAPPFinder An accessory program that works with GenMAPP and Gene Ontology to identify global biological trends in gene expression data
• TIGR Analyze gene expression data and apply basic and advanced clustering tools
• TRANSFAC Database on eukaryotic transcription factors, their genomic binding sites and DNA-binding profiles
• unCHIP Convert Affymetrix^® probe set numbers into meaningful values